Promoter from Chinese hamster elongation factor-1a gene and Epstein-Barr virus terminal repeats concatemer fragment maintain stable high-level expression of recombinant proteins

BACKGROUND: The Chinese hamster ovary (CHO) cell line is the main host for the high-titer production of therapeutic and diagnostic proteins in the biopharmaceutical industry. In most cases, plasmids for efficient protein expression in CHO cells are based on the cytomegalovirus (CMV) promoter. The au...

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Detalles Bibliográficos
Autores principales: Sinegubova, Maria V., Orlova, Nadezhda A., Vorobiev, Ivan I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: PeerJ Inc. 2023
Materias:
Biotechnology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10607201/
https://www.ncbi.nlm.nih.gov/pubmed/37901457
http://dx.doi.org/10.7717/peerj.16287

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10607201/
https://www.ncbi.nlm.nih.gov/pubmed/37901457
http://dx.doi.org/10.7717/peerj.16287

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