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Photo- and Sono-Active Food Colorants Inactivating Bacteria
Food colorants are commonly used as excipients in pharmaceutical and nutraceutical fields, but they have a wide range of other potential applications, for instance, as cytotoxic drugs or mediators of physical antimicrobial treatments. The photodynamic antibacterial activity of several edible food co...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10607222/ https://www.ncbi.nlm.nih.gov/pubmed/37894807 http://dx.doi.org/10.3390/ijms242015126 |
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author | Hochma, Efrat Hovor, Iryna Nakonechny, Faina Nisnevitch, Marina |
author_facet | Hochma, Efrat Hovor, Iryna Nakonechny, Faina Nisnevitch, Marina |
author_sort | Hochma, Efrat |
collection | PubMed |
description | Food colorants are commonly used as excipients in pharmaceutical and nutraceutical fields, but they have a wide range of other potential applications, for instance, as cytotoxic drugs or mediators of physical antimicrobial treatments. The photodynamic antibacterial activity of several edible food colorants is reported here, including E127, E129, E124, E122, E133, and E150a, alongside Rhein, a natural lipophilic antibacterial and anticancer compound found in medicinal plants. Minimal inhibitory concentration (MIC) values for S. aureus and E. coli showed that E127 and Rhein were effective against both bacteria, while other colorants exhibited low activity against E. coli. In some cases, dark pre-incubation of the colorants with Gram-positive S. aureus increased their photodynamic activity. Adding Rhein to E127 increased the photodynamic activity of the latter in a supportive mode. Optional sensing mechanism pathways of combined E127/Rhein action were suggested. The antibacterial activity of the studied colorants can be ranged as follows: E127/Rhein >> E127 >> E150a > E122 > E124 >> E129 ≈ E133. E127 was also found to exhibit photodynamic properties. Short ultrasonic treatment before illumination caused intensification of E127 photodynamic activity against E. coli when applied alone and especially in combination with Rhein. Food colorants exhibiting photo- and sonodynamic properties may have good potential in food preservation. |
format | Online Article Text |
id | pubmed-10607222 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-106072222023-10-28 Photo- and Sono-Active Food Colorants Inactivating Bacteria Hochma, Efrat Hovor, Iryna Nakonechny, Faina Nisnevitch, Marina Int J Mol Sci Article Food colorants are commonly used as excipients in pharmaceutical and nutraceutical fields, but they have a wide range of other potential applications, for instance, as cytotoxic drugs or mediators of physical antimicrobial treatments. The photodynamic antibacterial activity of several edible food colorants is reported here, including E127, E129, E124, E122, E133, and E150a, alongside Rhein, a natural lipophilic antibacterial and anticancer compound found in medicinal plants. Minimal inhibitory concentration (MIC) values for S. aureus and E. coli showed that E127 and Rhein were effective against both bacteria, while other colorants exhibited low activity against E. coli. In some cases, dark pre-incubation of the colorants with Gram-positive S. aureus increased their photodynamic activity. Adding Rhein to E127 increased the photodynamic activity of the latter in a supportive mode. Optional sensing mechanism pathways of combined E127/Rhein action were suggested. The antibacterial activity of the studied colorants can be ranged as follows: E127/Rhein >> E127 >> E150a > E122 > E124 >> E129 ≈ E133. E127 was also found to exhibit photodynamic properties. Short ultrasonic treatment before illumination caused intensification of E127 photodynamic activity against E. coli when applied alone and especially in combination with Rhein. Food colorants exhibiting photo- and sonodynamic properties may have good potential in food preservation. MDPI 2023-10-12 /pmc/articles/PMC10607222/ /pubmed/37894807 http://dx.doi.org/10.3390/ijms242015126 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Hochma, Efrat Hovor, Iryna Nakonechny, Faina Nisnevitch, Marina Photo- and Sono-Active Food Colorants Inactivating Bacteria |
title | Photo- and Sono-Active Food Colorants Inactivating Bacteria |
title_full | Photo- and Sono-Active Food Colorants Inactivating Bacteria |
title_fullStr | Photo- and Sono-Active Food Colorants Inactivating Bacteria |
title_full_unstemmed | Photo- and Sono-Active Food Colorants Inactivating Bacteria |
title_short | Photo- and Sono-Active Food Colorants Inactivating Bacteria |
title_sort | photo- and sono-active food colorants inactivating bacteria |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10607222/ https://www.ncbi.nlm.nih.gov/pubmed/37894807 http://dx.doi.org/10.3390/ijms242015126 |
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