Cranial Neural Crest Specific Deletion of Alpl (TNAP) via P0-Cre Causes Abnormal Chondrocyte Maturation and Deficient Cranial Base Growth

Bone growth plate abnormalities and skull shape defects are seen in hypophosphatasia, a heritable disorder in humans that occurs due to the deficiency of tissue nonspecific alkaline phosphatase (TNAP, Alpl) enzyme activity. The abnormal development of the cranial base growth plates (synchondroses) a...

Descripción completa

Detalles Bibliográficos
Autores principales: Ohkura, Naoto, Nam, Hwa Kyung, Liu, Fei, Hatch, Nan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10607232/
https://www.ncbi.nlm.nih.gov/pubmed/37895082
http://dx.doi.org/10.3390/ijms242015401

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10607232/
https://www.ncbi.nlm.nih.gov/pubmed/37895082
http://dx.doi.org/10.3390/ijms242015401

Ejemplares similares