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Cranial Neural Crest Specific Deletion of Alpl (TNAP) via P0-Cre Causes Abnormal Chondrocyte Maturation and Deficient Cranial Base Growth

Bone growth plate abnormalities and skull shape defects are seen in hypophosphatasia, a heritable disorder in humans that occurs due to the deficiency of tissue nonspecific alkaline phosphatase (TNAP, Alpl) enzyme activity. The abnormal development of the cranial base growth plates (synchondroses) a...

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Detalles Bibliográficos
Autores principales:	Ohkura, Naoto, Nam, Hwa Kyung, Liu, Fei, Hatch, Nan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10607232/ https://www.ncbi.nlm.nih.gov/pubmed/37895082 http://dx.doi.org/10.3390/ijms242015401

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