Tryptophan-Starved Human Cells Overexpressing Tryptophanyl-tRNA Synthetase Enhance High-Affinity Tryptophan Uptake via Enzymatic Production of Tryptophanyl-AMP

Our previous study demonstrated that L-tryptophan (Trp)-depleted cells display a marked enhancement in Trp uptake facilitated by extracellular tryptophanyl-tRNA synthetase (TrpRS). Here, we show that Trp uptake into TrpRS-overexpressing cells is also markedly elevated upon Trp starvation. These find...

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Detalles Bibliográficos
Autores principales: Yokosawa, Takumi, Wakasugi, Keisuke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10607379/
https://www.ncbi.nlm.nih.gov/pubmed/37895133
http://dx.doi.org/10.3390/ijms242015453

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10607379/
https://www.ncbi.nlm.nih.gov/pubmed/37895133
http://dx.doi.org/10.3390/ijms242015453

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