Search for Novel Therapies for Essential Tremor Based on Positive Modulation of α6-Containing GABA(A) Receptors

BACKGROUND: Prior work using GABA(A) receptor subunit knockouts and the harmaline model has indicated that low-dose alcohol, gaboxadol, and ganaxolone suppress tremor via α6βδ GABA(A) receptors. This suggests that drugs specifically enhancing the action of α6βδ or α6βγ2 GABA(A) receptors, both predo...

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Detalles Bibliográficos
Autores principales: Handforth, Adrian, Singh, Ram P., Treven, Marco, Ernst, Margot
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ubiquity Press 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10607569/
https://www.ncbi.nlm.nih.gov/pubmed/37900009
http://dx.doi.org/10.5334/tohm.796

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10607569/
https://www.ncbi.nlm.nih.gov/pubmed/37900009
http://dx.doi.org/10.5334/tohm.796

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