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Search for Novel Therapies for Essential Tremor Based on Positive Modulation of α6-Containing GABA(A) Receptors
BACKGROUND: Prior work using GABA(A) receptor subunit knockouts and the harmaline model has indicated that low-dose alcohol, gaboxadol, and ganaxolone suppress tremor via α6βδ GABA(A) receptors. This suggests that drugs specifically enhancing the action of α6βδ or α6βγ2 GABA(A) receptors, both predo...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Ubiquity Press
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10607569/ https://www.ncbi.nlm.nih.gov/pubmed/37900009 http://dx.doi.org/10.5334/tohm.796 |