Endothelial Cell Dysfunction and Hypoxia as Potential Mediators of Pain in Fabry Disease: A Human-Murine Translational Approach

Fabry disease (FD) is caused by α-galactosidase A (AGAL) enzyme deficiency, leading to globotriaosylceramide accumulation (Gb3) in several cell types. Pain is one of the pathophysiologically incompletely understood symptoms in FD patients. Previous data suggest an involvement of hypoxia and mitochon...

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Detalles Bibliográficos
Autores principales: Klug, Katharina, Spitzel, Marlene, Hans, Clara, Klein, Alexandra, Schottmann, Nicole Michelle, Erbacher, Christoph, Üçeyler, Nurcan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10607880/
https://www.ncbi.nlm.nih.gov/pubmed/37895103
http://dx.doi.org/10.3390/ijms242015422

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10607880/
https://www.ncbi.nlm.nih.gov/pubmed/37895103
http://dx.doi.org/10.3390/ijms242015422

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