Cargando…

The RANK–RANKL–OPG System: A Multifaceted Regulator of Homeostasis, Immunity, and Cancer

The RANK–RANKL–OPG system is a complex signaling pathway that plays a critical role in bone metabolism, mammary epithelial cell development, immune function, and cancer. RANKL is a ligand that binds to RANK, a receptor expressed on osteoclasts, dendritic cells, T cells, and other cells. RANKL signal...

Descripción completa

Detalles Bibliográficos
Autores principales:	De Leon-Oliva, Diego, Barrena-Blázquez, Silvestra, Jiménez-Álvarez, Laura, Fraile-Martinez, Oscar, García-Montero, Cielo, López-González, Laura, Torres-Carranza, Diego, García-Puente, Luis M., Carranza, Sara T., Álvarez-Mon, Miguel Ángel, Álvarez-Mon, Melchor, Diaz, Raul, Ortega, Miguel A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10608105/ https://www.ncbi.nlm.nih.gov/pubmed/37893470 http://dx.doi.org/10.3390/medicina59101752

Ejemplares similares

Unraveling the New Perspectives on Antimicrobial Hydrogels: State-of-the-Art and Translational Applications
por: Ortega, Miguel A., et al.
Publicado: (2023)

The Pivotal Role of the Placenta in Normal and Pathological Pregnancies: A Focus on Preeclampsia, Fetal Growth Restriction, and Maternal Chronic Venous Disease
por: Ortega, Miguel A., et al.
Publicado: (2022)

An integrative look at SARS-CoV-2 (Review)
por: Ortega, Miguel A., et al.
Publicado: (2021)

Assessment of Tissue Expression of the Oxytocin–Vasopressin Pathway in the Placenta of Women with a First-Episode Psychosis during Pregnancy
por: Ortega, Miguel A., et al.
Publicado: (2023)

Updated Views in Targeted Therapy in the Patient with Non-Small Cell Lung Cancer
por: Ortega, Miguel A., et al.
Publicado: (2023)

Reframing the link between metabolism and NLRP3 inflammasome: therapeutic opportunities
por: Ortega, Miguel A., et al.
Publicado: (2023)

Understanding HAT1: A Comprehensive Review of Noncanonical Roles and Connection with Disease
por: Ortega, Miguel A., et al.
Publicado: (2023)

RANK/RANKL/OPG system in the intervertebral disc
por: Takegami, Norihiko, et al.
Publicado: (2017)

Microbiota–gut–brain axis mechanisms in the complex network of bipolar disorders: potential clinical implications and translational opportunities
por: Ortega, Miguel A., et al.
Publicado: (2023)

A comprehensive look at the psychoneuroimmunoendocrinology of spinal cord injury and its progression: mechanisms and clinical opportunities
por: Ortega, Miguel A., et al.
Publicado: (2023)

An Overview of the Role of MicroRNAs on Carcinogenesis: A Focus on Cell Cycle, Angiogenesis and Metastasis
por: Pekarek, Leonel, et al.
Publicado: (2023)

An Updated Review of SARS-CoV-2 Vaccines and the Importance of Effective Vaccination Programs in Pandemic Times
por: García-Montero, Cielo, et al.
Publicado: (2021)

Exploring Perceptions About Paracetamol, Tramadol, and Codeine on Twitter Using Machine Learning: Quantitative and Qualitative Observational Study
por: Carabot, Federico, et al.
Publicado: (2023)

Patients with Invasive Lobular Carcinoma Show a Significant Increase in IRS-4 Expression Compared to Infiltrative Ductal Carcinoma—A Histopathological Study
por: Ortega, Miguel A., et al.
Publicado: (2022)

Targeting the RANKL/RANK/OPG Axis for Cancer Therapy
por: Ming, Jie, et al.
Publicado: (2020)

Quality of Life of Patients Treated for Abdominal Aortic Aneurysm: Open Surgery and Endoprosthesis
por: Barrena-Blázquez, Silvestra, et al.
Publicado: (2022)

Association of Age and Surgical Technique with the Quality of Life of Male Patients Treated for Abdominal Aorta Aneurysms: A Cross-Sectional Study
por: Barrena-Blázquez, Silvestra, et al.
Publicado: (2022)

Immune-Mediated Diseases from the Point of View of Psychoneuroimmunoendocrinology
por: Ortega, Miguel A., et al.
Publicado: (2022)

Quality of Life for Patients Receiving Elective Interventions for Abdominal Aortic Aneurysms
por: Barrena-Blázquez, Silvestra, et al.
Publicado: (2022)

A General Overview on the Hyperbaric Oxygen Therapy: Applications, Mechanisms and Translational Opportunities
por: Ortega, Miguel A., et al.
Publicado: (2021)

Exploring the Role of Mediterranean and Westernized Diets and Their Main Nutrients in the Modulation of Oxidative Stress in the Placenta: A Narrative Review
por: García-Montero, Cielo, et al.
Publicado: (2023)

Modification of the Polymer of a Bone Cement with Biodegradable Microspheres of PLGA and Loading with Daptomycin and Vancomycin Improve the Response to Bone Tissue Infection
por: García-García, Joaquin, et al.
Publicado: (2022)

Exploring the Role of Nutraceuticals in Major Depressive Disorder (MDD): Rationale, State of the Art and Future Prospects
por: Alvarez-Mon, Miguel A., et al.
Publicado: (2021)

Chronic venous disease patients show increased IRS-4 expression in the great saphenous vein wall
por: Ortega, Miguel A, et al.
Publicado: (2021)

Understanding Chronic Venous Disease: A Critical Overview of Its Pathophysiology and Medical Management
por: Ortega, Miguel A., et al.
Publicado: (2021)

Understanding the basis of major depressive disorder in oncological patients: Biological links, clinical management, challenges, and lifestyle medicine
por: Fraile-Martinez, Oscar, et al.
Publicado: (2022)

An Updated View of the Importance of Vesicular Trafficking and Transport and Their Role in Immune-Mediated Diseases: Potential Therapeutic Interventions
por: Ortega, Miguel A., et al.
Publicado: (2022)

Understanding Public Perceptions and Discussions on Opioids Through Twitter: Cross-Sectional Infodemiology Study
por: Carabot, Federico, et al.
Publicado: (2023)

Oxidative Stress Markers Are Associated with a Poor Prognosis in Patients with Pancreatic Cancer
por: Ortega, Miguel A., et al.
Publicado: (2022)

Contribution of the Elastic Component and Venous Wall Arterialization in Patients with Venous Reflux
por: Ortega, Miguel A., et al.
Publicado: (2022)

Biology of the RANKL–RANK–OPG System in Immunity, Bone, and Beyond
por: Walsh, Matthew C., et al.
Publicado: (2014)

Dysregulation of the RANKL/RANK/OPG axis in thalassemia intermedia patients
por: Alfaqih, Mahmoud A., et al.
Publicado: (2018)

Rank-Rankl-Opg Axis in Multiple Sclerosis: The Contribution of Placenta
por: Passaponti, Sofia, et al.
Publicado: (2022)

Towards an updated view on the clinical management of pancreatic adenocarcinoma: Current and future perspectives
por: Pekarek, Leonel, et al.
Publicado: (2021)

Gut Microbiota Metabolites in Major Depressive Disorder—Deep Insights into Their Pathophysiological Role and Potential Translational Applications
por: Ortega, Miguel A., et al.
Publicado: (2022)

Exploring histopathological and serum biomarkers in lung adenocarcinoma: Clinical applications and translational opportunities (Review)
por: Ortega, Miguel A., et al.
Publicado: (2022)

Tissue remodelling and increased DNA damage in patients with incompetent valves in chronic venous insufficiency
por: Ortega, Miguel A., et al.
Publicado: (2021)

AIF1: Function and Connection with Inflammatory Diseases
por: De Leon-Oliva, Diego, et al.
Publicado: (2023)

Clinical and Translational Applications of Serological and Histopathological Biomarkers in Metastatic Breast Cancer: A Comprehensive Review
por: Pekarek, Leonel, et al.
Publicado: (2023)

Overexpression of glycolysis markers in placental tissue of pregnant women with chronic venous disease: a histological study
por: Ortega, Miguel A, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_45hiei9sk596rska2glk75ft0m