Implications of Tioguanine Dosing in IBD Patients with a TPMT Deficiency

Tioguanine is metabolised by fewer enzymatic steps compared to azathioprine and mercaptopurine, without generating 6-methylmercaptopurine ribonucleotides. However, thiopurine S-methyl transferase (TPMT) plays a role in early toxicity in all thiopurines. We aimed to describe the hazards and opportuni...

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Detalles Bibliográficos
Autores principales: Deben, Debbie S., Derijks, Luc J. J., van den Bosch, Bianca J. C., Creemers, Rob H., van Nunen, Annick, van Bodegraven, Adriaan A., Wong, Dennis R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10608562/
https://www.ncbi.nlm.nih.gov/pubmed/37887379
http://dx.doi.org/10.3390/metabo13101054

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10608562/
https://www.ncbi.nlm.nih.gov/pubmed/37887379
http://dx.doi.org/10.3390/metabo13101054

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