Structural Identification of Zotarolimus (ABT-578) Metabolites Generated by Human Liver Microsomes Using Ion-Trap and High-Resolution Time-of-Flight Mass Spectrometry in Combination with the Analysis of Fragmentation Patterns

Zotarolimus (ABT-578) is a sirolimus derivative that, like sirolimus and everolimus, is an inhibitor of cell growth via inhibition of the mechanistic target of rapamycin (mTOR). Zotarolimus was developed for coating coronary stents to prevent smooth muscle cell proliferation and restenosis. Albeit z...

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Detalles Bibliográficos
Autores principales: Shokati, Touraj, Drake, Seth H., Zhao, Wanzhu, Klawitter, Jost, Klawitter, Jelena, Christians, Uwe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10608723/
https://www.ncbi.nlm.nih.gov/pubmed/37887418
http://dx.doi.org/10.3390/metabo13101093

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10608723/
https://www.ncbi.nlm.nih.gov/pubmed/37887418
http://dx.doi.org/10.3390/metabo13101093

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