Two Birds with One Stone: A Novel Dithiomaleimide-Based GalNAc-siRNA Conjugate Enabling Good siRNA Delivery and Traceability

For the first time, a novel dithiomaleimides (DTM) based tetra-antennary GalNAc conjugate was developed, which enable both efficient siRNA delivery and good traceability, without incorporating extra fluorophores. This conjugate can be readily constructed by three click-type reactions, that is, amida...

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Detalles Bibliográficos
Autores principales: Kong, Sudong, Gao, Xiaoqing, Wang, Qianhui, Lin, Jianguo, Qiu, Ling, Xie, Minhao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10609014/
https://www.ncbi.nlm.nih.gov/pubmed/37894663
http://dx.doi.org/10.3390/molecules28207184

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10609014/
https://www.ncbi.nlm.nih.gov/pubmed/37894663
http://dx.doi.org/10.3390/molecules28207184

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