A Computational Workflow to Predict Biological Target Mutations: The Spike Glycoprotein Case Study

The biological target identification process, a pivotal phase in the drug discovery workflow, becomes particularly challenging when mutations affect proteins’ mechanisms of action. COVID-19 Spike glycoprotein mutations are known to modify the affinity toward the human angiotensin-converting enzyme A...

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Detalles Bibliográficos
Autores principales: Cozzini, Pietro, Agosta, Federica, Dolcetti, Greta, Dal Palù, Alessandro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10609230/
https://www.ncbi.nlm.nih.gov/pubmed/37894561
http://dx.doi.org/10.3390/molecules28207082

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10609230/
https://www.ncbi.nlm.nih.gov/pubmed/37894561
http://dx.doi.org/10.3390/molecules28207082

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