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A Computational Workflow to Predict Biological Target Mutations: The Spike Glycoprotein Case Study

The biological target identification process, a pivotal phase in the drug discovery workflow, becomes particularly challenging when mutations affect proteins’ mechanisms of action. COVID-19 Spike glycoprotein mutations are known to modify the affinity toward the human angiotensin-converting enzyme A...

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Detalles Bibliográficos
Autores principales:	Cozzini, Pietro, Agosta, Federica, Dolcetti, Greta, Dal Palù, Alessandro
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10609230/ https://www.ncbi.nlm.nih.gov/pubmed/37894561 http://dx.doi.org/10.3390/molecules28207082

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