Inhibition of the NOTCH and mTOR pathways by nelfinavir as a novel treatment for T cell acute lymphoblastic leukemia

T cell acute lymphoblastic leukemia (T-ALL), a neoplasm derived from T cell lineage-committed lymphoblasts, is characterized by genetic alterations that result in activation of oncogenic transcription factors and the NOTCH1 pathway activation. The NOTCH is a transmembrane receptor protein activated...

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Detalles Bibliográficos
Autores principales: Chang, Yoon Soo, Gills, Joell J., Kawabata, Shigeru, Onozawa, Masahiro, Della Gatta, Giusy, Ferrando, Adolfo A., Aplan, Peter D., Dennis, Phillip A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2023
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10609462/
https://www.ncbi.nlm.nih.gov/pubmed/37800623
http://dx.doi.org/10.3892/ijo.2023.5576

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10609462/
https://www.ncbi.nlm.nih.gov/pubmed/37800623
http://dx.doi.org/10.3892/ijo.2023.5576

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