Site-Specific Structural Changes in Long-Term-Stressed Monoclonal Antibody Revealed with DEPC Covalent-Labeling and Quantitative Mass Spectrometry

Studies of structural changes in mAbs under forced stress and storage conditions are essential for the recognition of degradation hotspots, which can be further remodeled to improve the stability of the respective protein. Herein, we used diethyl pyrocarbonate (DEPC)-based covalent labeling mass spe...

Descripción completa

Detalles Bibliográficos
Autores principales: Gaikwad, Manasi, Richter, Florian, Götz, Rabea, Dörrbaum, Aline, Schumacher, Lena, Tonillo, Jason, Frech, Christian, Kellner, Roland, Hopf, Carsten
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10609731/
https://www.ncbi.nlm.nih.gov/pubmed/37895889
http://dx.doi.org/10.3390/ph16101418

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10609731/
https://www.ncbi.nlm.nih.gov/pubmed/37895889
http://dx.doi.org/10.3390/ph16101418

Ejemplares similares