Targeting Lactate Dehydrogenase-B as a Strategy to Fight Cancer: Identification of Potential Inhibitors by In Silico Analysis and In Vitro Screening

Lactate dehydrogenase (LDH) is an enzyme that catalyzes the reversible conversion of lactate to pyruvate while reducing NAD(+) to NADH (or oxidizing NADH to NAD(+)). Due to its central role in the Warburg effect, LDH-A isoform has been considered a promising target for treating several types of canc...

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Detalles Bibliográficos
Autores principales: Vlasiou, Manos, Nicolaidou, Vicky, Papaneophytou, Christos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10609963/
https://www.ncbi.nlm.nih.gov/pubmed/37896171
http://dx.doi.org/10.3390/pharmaceutics15102411

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10609963/
https://www.ncbi.nlm.nih.gov/pubmed/37896171
http://dx.doi.org/10.3390/pharmaceutics15102411

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