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Targeting Lactate Dehydrogenase-B as a Strategy to Fight Cancer: Identification of Potential Inhibitors by In Silico Analysis and In Vitro Screening
Lactate dehydrogenase (LDH) is an enzyme that catalyzes the reversible conversion of lactate to pyruvate while reducing NAD(+) to NADH (or oxidizing NADH to NAD(+)). Due to its central role in the Warburg effect, LDH-A isoform has been considered a promising target for treating several types of canc...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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MDPI
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10609963/ https://www.ncbi.nlm.nih.gov/pubmed/37896171 http://dx.doi.org/10.3390/pharmaceutics15102411 |