Exploring the basis of heterogeneity of cancer aggressiveness among the mutated POLE variants

Germline pathogenic variants in the exonuclease domain of the replicative DNA polymerase Pol ε encoded by the POLE gene, predispose essentially to colorectal and endometrial tumors by inducing an ultramutator phenotype. It is still unclear whether all the POLE alterations influence similar strength...

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Detalles Bibliográficos
Autores principales: Selves, Janick, de Castro e Gloria, Helena, Brunac, Anne-Cécile, Saffi, Jenifer, Guimbaud, Rosine, Brousset, Pierre, Hoffmann, Jean-Sébastien
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Life Science Alliance LLC 2023
Materias:
Reviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10610022/
https://www.ncbi.nlm.nih.gov/pubmed/37891003
http://dx.doi.org/10.26508/lsa.202302290

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10610022/
https://www.ncbi.nlm.nih.gov/pubmed/37891003
http://dx.doi.org/10.26508/lsa.202302290

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