APR-246 increases tumor antigenicity independent of p53

We previously reported that activation of p53 by APR-246 reprograms tumor-associated macrophages to overcome immune checkpoint blockade resistance. Here, we demonstrate that APR-246 and its active moiety, methylene quinuclidinone (MQ) can enhance the immunogenicity of tumor cells directly. MQ treatm...

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Detalles Bibliográficos
Autores principales: Michels, Judith, Venkatesh, Divya, Liu, Cailian, Budhu, Sadna, Zhong, Hong, George, Mariam M, Thach, Daniel, Yao, Zhong-Ke, Ouerfelli, Ouathek, Liu, Hengrui, Stockwell, Brent R, Campesato, Luis Felipe, Zamarin, Dmitriy, Zappasodi, Roberta, Wolchok, Jedd D, Merghoub, Taha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Life Science Alliance LLC 2023
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10610029/
https://www.ncbi.nlm.nih.gov/pubmed/37891002
http://dx.doi.org/10.26508/lsa.202301999

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10610029/
https://www.ncbi.nlm.nih.gov/pubmed/37891002
http://dx.doi.org/10.26508/lsa.202301999

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