Verubulin (Azixa) Analogues with Increased Saturation: Synthesis, SAR and Encapsulation in Biocompatible Nanocontainers Based on Ca(2+) or Mg(2+) Cross-Linked Alginate

Tubulin-targeting agents attract undiminished attention as promising compounds for the design of anti-cancer drugs. Verubulin is a potent tubulin polymerization inhibitor, binding to colchicine-binding sites. In the present work, a series of verubulin analogues containing a cyclohexane or cyclohepta...

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Detalles Bibliográficos
Autores principales: Sedenkova, Kseniya N., Leschukov, Denis N., Grishin, Yuri K., Zefirov, Nikolay A., Gracheva, Yulia A., Skvortsov, Dmitry A., Hrytseniuk, Yanislav S., Vasilyeva, Lilja A., Spirkova, Elena A., Shevtsov, Pavel N., Shevtsova, Elena F., Lukmanova, Alina R., Spiridonov, Vasily V., Markova, Alina A., Nguyen, Minh T., Shtil, Alexander A., Zefirova, Olga N., Yaroslavov, Alexander A., Milaeva, Elena R., Averina, Elena B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10610134/
https://www.ncbi.nlm.nih.gov/pubmed/37895970
http://dx.doi.org/10.3390/ph16101499

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10610134/
https://www.ncbi.nlm.nih.gov/pubmed/37895970
http://dx.doi.org/10.3390/ph16101499

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