Structure–Activity Relationship Studies of Chalcones and Diarylpentanoids with Antitumor Activity: Potency and Selectivity Optimization

We previously reported that chalcone CM-M345 (1) and diarylpentanoid BP-C4 (2) induced p53-dependent growth inhibitory activity in human cancer cells. Herein, CM-M345 (1) and BP-C4 (2) analogues were designed and synthesized in order to obtain more potent and selective compounds. Compounds 16, 17, 1...

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Detalles Bibliográficos
Autores principales: Moreira, Joana, Loureiro, Joana B., Correia, Danilo, Palmeira, Andreia, Pinto, Madalena M., Saraiva, Lucília, Cidade, Honorina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10610188/
https://www.ncbi.nlm.nih.gov/pubmed/37895825
http://dx.doi.org/10.3390/ph16101354

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10610188/
https://www.ncbi.nlm.nih.gov/pubmed/37895825
http://dx.doi.org/10.3390/ph16101354

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