Excipient Impact on Fenofibrate Equilibrium Solubility in Fasted and Fed Simulated Intestinal Fluids Assessed Using a Design of Experiment Protocol

Solubility is a critical parameter controlling drug absorption after oral administration. For poorly soluble drugs, solubility is influenced by the complex composition of intestinal media and the influence of dosage form excipients, which can cause bioavailability and bioequivalence issues. This stu...

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Detalles Bibliográficos
Autores principales: Ainousah, Bayan E., Khadra, Ibrahim, Halbert, Gavin W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10610309/
https://www.ncbi.nlm.nih.gov/pubmed/37896244
http://dx.doi.org/10.3390/pharmaceutics15102484

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10610309/
https://www.ncbi.nlm.nih.gov/pubmed/37896244
http://dx.doi.org/10.3390/pharmaceutics15102484

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