Cargando…

Thiadiazolidinone (TDZD) Analogs Inhibit Aggregation-Mediated Pathology in Diverse Neurodegeneration Models, and Extend C. elegans Life- and Healthspan

Chronic, low-grade inflammation has been implicated in aging and age-dependent conditions, including Alzheimer’s disease, cardiomyopathy, and cancer. One of the age-associated processes underlying chronic inflammation is protein aggregation, which is implicated in neuroinflammation and a broad spect...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kakraba, Samuel, Ayyadevara, Srinivas, Mainali, Nirjal, Balasubramaniam, Meenakshisundaram, Bowroju, Suresh, Penthala, Narsimha Reddy, Atluri, Ramani, Barger, Steven W., Griffin, Sue T., Crooks, Peter A., Shmookler Reis, Robert J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10610358/ https://www.ncbi.nlm.nih.gov/pubmed/37895969 http://dx.doi.org/10.3390/ph16101498

Ejemplares similares

Structural modeling of GSK3β implicates the inactive (DFG-out) conformation as the target bound by TDZD analogs
por: Balasubramaniam, Meenakshisundaram, et al.
Publicado: (2020)

Design and Synthesis of Novel Hybrid 8-Hydroxy Quinoline-Indole Derivatives as Inhibitors of Aβ Self-Aggregation and Metal Chelation-Induced Aβ Aggregation
por: Bowroju, Suresh K., et al.
Publicado: (2020)

Inhibition of Glioblastoma Growth by the Thiadiazolidinone Compound TDZD-8
por: Aguilar-Morante, Diana, et al.
Publicado: (2010)

Physiological Consequences of Targeting 14-3-3 and Its Interacting Partners in Neurodegenerative Diseases
por: Ganne, Akshatha, et al.
Publicado: (2022)

Aggregate Interactome Based on Protein Cross-linking Interfaces Predicts Drug Targets to Limit Aggregation in Neurodegenerative Diseases
por: Balasubramaniam, Meenakshisundaram, et al.
Publicado: (2019)

A Novel Microtubule-Binding Drug Attenuates and Reverses Protein Aggregation in Animal Models of Alzheimer’s Disease
por: Kakraba, Samuel, et al.
Publicado: (2019)

Intrinsically disordered proteins identified in the aggregate proteome serve as biomarkers of neurodegeneration
por: Ayyadevara, Srinivas, et al.
Publicado: (2021)

“Protein aggregates” contain RNA and DNA, entrapped by misfolded proteins but largely rescued by slowing translational elongation
por: Shmookler Reis, Robert J., et al.
Publicado: (2021)

Machine-learning analysis of intrinsically disordered proteins identifies key factors that contribute to neurodegeneration-related aggregation
por: Ganne, Akshatha, et al.
Publicado: (2022)

Structural insights into pro-aggregation effects of C. elegans CRAM-1 and its human ortholog SERF2
por: Balasubramaniam, Meenakshisundaram, et al.
Publicado: (2018)

Protein homeostasis in the aged and diseased heart
por: Mainali, Nirjal, et al.
Publicado: (2023)

Proteins in aggregates functionally impact multiple neurodegenerative disease models by forming proteasome-blocking complexes
por: Ayyadevara, Srinivas, et al.
Publicado: (2015)

PIP(3)-binding proteins promote age-dependent protein aggregation and limit survival in C. elegans
por: Ayyadevara, Srinivas, et al.
Publicado: (2016)

Glial Fibrillary Acidic Protein: A Biomarker and Drug Target for Alzheimer’s Disease
por: Ganne, Akshatha, et al.
Publicado: (2022)

Proteins that mediate protein aggregation and cytotoxicity distinguish Alzheimer's hippocampus from normal controls
por: Ayyadevara, Srinivas, et al.
Publicado: (2016)

Apolipoprotein E4 inhibits autophagy gene products through direct, specific binding to CLEAR motifs
por: Parcon, Paul A., et al.
Publicado: (2017)

Extreme Depletion of PIP(3) Accompanies the Increased Life Span and Stress Tolerance of PI3K-null C. elegans Mutants
por: Bharill, Puneet, et al.
Publicado: (2013)

In silico analysis of TUBA4A mutations in Amyotrophic Lateral Sclerosis to define mechanisms of microtubule disintegration
por: Ganne, Akshatha, et al.
Publicado: (2023)

Proteins that accumulate with age in human skeletal-muscle aggregates contribute to declines in muscle mass and function in Caenorhabditis elegans
por: Ayyadevara, Srinivas, et al.
Publicado: (2016)

Inhibition of the SARS-CoV-2 main protease by a thiadiazolidinone derivative
por: Jovic, Katarina, et al.
Publicado: (2023)

rac-5-Bromo-N-benzylisatincreatinine ethanol monosolvate
por: Penthala, Narsimha Reddy, et al.
Publicado: (2013)

rac-N-Benzylisatincreatinine (unknown solvate)
por: Penthala, Narsimha Reddy, et al.
Publicado: (2013)

Computational target-based drug repurposing of elbasvir, an antiviral drug predicted to bind multiple SARS-CoV-2 proteins
por: Balasubramaniam, Meenakshisundaram, et al.
Publicado: (2020)

Rec-8 dimorphism affects longevity, stress resistance and X-chromosome nondisjunction in C. elegans, and replicative lifespan in S. cerevisiae
por: Ayyadevara, Srinivas, et al.
Publicado: (2014)

(Z)-3-(1H-Indol-3-yl)-2-(3,4,5-trimethoxyphenyl)acrylonitrile
por: Penthala, Narsimha Reddy, et al.
Publicado: (2012)

(Z)-3-(1-Benzofuran-2-yl)-2-(3,4,5-trimethoxyphenyl)acrylonitrile
por: Penthala, Narsimha Reddy, et al.
Publicado: (2012)

A Small-Molecule Inhibitor of RAD51 Reduces Homologous Recombination and Sensitizes Multiple Myeloma Cells to Doxorubicin
por: Alagpulinsa, David A., et al.
Publicado: (2014)

Imaging Pulmonary NF-kappaB Activation and Therapeutic Effects of MLN120B and TDZD-8
por: Ansaldi, Dan, et al.
Publicado: (2011)

13-(Imidazol-1-yl)-11,13-dihydromelampomagnolide B monohydrate
por: Janganati, Venumadhav, et al.
Publicado: (2013)

Crystal structure of (E)-13-(pyrimidin-5-yl)parthenolide
por: Bommagani, Shobanbabu, et al.
Publicado: (2015)

Positive Feedback between Transcriptional and Kinase Suppression in Nematodes with Extraordinary Longevity and Stress Resistance
por: Tazearslan, Çagdaþ, et al.
Publicado: (2009)

A universal transcriptomic signature of age reveals the temporal scaling of Caenorhabditis elegans aging trajectories
por: Tarkhov, Andrei E., et al.
Publicado: (2019)

rac-(Z)-Methyl 1-benzyl-3-[(3-hydroxyquinuclidin-2-ylidene)methyl]-1H-indole-6-carboxylate
por: Penthala, Narsimha Reddy, et al.
Publicado: (2012)

A Narrow Quantitative Trait Locus in C. elegans Coordinately Affects Longevity, Thermotolerance, and Resistance to Paraquat
por: Vertino, Anthony, et al.
Publicado: (2011)

(Z)-Methyl 4-[3-(3-oxoquinuclidin-2-ylidenemethyl)-1H-indol-1-ylmethyl]benzoate
por: Reddy, Thirupathi Reddy Yerram, et al.
Publicado: (2008)

(Z)-4-[3-(3-Oxoquinuclidin-2-ylidenemethyl)-1H-indol-1-ylmethyl]benzonitrile
por: Reddy, Thirupathi Reddy Yerram, et al.
Publicado: (2008)

(Z)-4-[3-(2,5-Dioxoimidazolidin-4-ylidenemethyl)-1H-indol-1-ylmethyl]benzonitrile
por: Penthala, Narsimha Reddy, et al.
Publicado: (2008)

(Z)-Methyl 4-({3-[(2,5-dioxoimidazolidin-4-ylidene)methyl]-1H-indol-1-yl}methyl)benzoate
por: Penthala, Narsimha Reddy, et al.
Publicado: (2008)

3-(2-Amino-1-methyl-4-oxo-4,5-dihydro-1H-imidazol-5-yl)-3-hydroxyindolin-2-one monohydrate
por: Penthala, Narsimha Reddy, et al.
Publicado: (2009)

rac-2-(2-Amino-4-oxo-4,5-dihydro-1,3-thiazol-5-yl)-2-hydroxyindane-1,3-dione
por: Penthala, Narsimha Reddy, et al.
Publicado: (2009)

Cannot write session to /tmp/vufind_sessions/sess_ocnq913mbu9l3kjed2nnumppc3