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Predicting Maternal and Infant Tetrahydrocannabinol Exposure in Lactating Cannabis Users: A Physiologically Based Pharmacokinetic Modeling Approach

A knowledge gap exists in infant tetrahydrocannabinol (THC) data to guide breastfeeding recommendations for mothers who use cannabis. In the present study, a paired lactation and infant physiologically based pharmacokinetic (PBPK) model was developed and verified. The verified model was used to simu...

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Detalles Bibliográficos
Autores principales: Shenkoya, Babajide, Yellepeddi, Venkata, Mark, Katrina, Gopalakrishnan, Mathangi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10610403/
https://www.ncbi.nlm.nih.gov/pubmed/37896227
http://dx.doi.org/10.3390/pharmaceutics15102467