Cargando…

Predicting Maternal and Infant Tetrahydrocannabinol Exposure in Lactating Cannabis Users: A Physiologically Based Pharmacokinetic Modeling Approach

A knowledge gap exists in infant tetrahydrocannabinol (THC) data to guide breastfeeding recommendations for mothers who use cannabis. In the present study, a paired lactation and infant physiologically based pharmacokinetic (PBPK) model was developed and verified. The verified model was used to simu...

Descripción completa

Detalles Bibliográficos
Autores principales:	Shenkoya, Babajide, Yellepeddi, Venkata, Mark, Katrina, Gopalakrishnan, Mathangi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10610403/ https://www.ncbi.nlm.nih.gov/pubmed/37896227 http://dx.doi.org/10.3390/pharmaceutics15102467

Ejemplares similares

Mechanistic Modeling of Maternal Lymphoid and Fetal Plasma Antiretroviral Exposure During the Third Trimester
por: Shenkoya, Babajide, et al.
Publicado: (2021)

Pharmacokinetics of delta-9-tetrahydrocannabinol following acute cannabis smoke exposure in mice; effects of sex, age, and strain
por: Gazarov, Emely A., et al.
Publicado: (2023)

Predicting Resolvin D1 Pharmacokinetics in Humans with Physiologically‐Based Pharmacokinetic Modeling
por: Yellepeddi, Venkata K., et al.
Publicado: (2020)

Les effets épigénétiques du cannabis/tétrahydrocannabinol()
por: Costentin, J.
Publicado: (2020)

Primaquine Pharmacokinetics in Lactating Women and Breastfed Infant Exposures
por: Gilder, Mary Ellen, et al.
Publicado: (2018)

Absence of Relevant Thermal Conversion of Cannabidiol to Tetrahydrocannabinol in E-Cigarette Vapor and Low-Tetrahydrocannabinol Cannabis Smoke
por: Hindelang, Pascal, et al.
Publicado: (2022)

Predictive modeling of aspirin‐triggered resolvin D1 pharmacokinetics for the study of Sjögren's syndrome
por: Yellepeddi, Venkata Kashyap, et al.
Publicado: (2019)

Pharmacokinetics of cannabichromene in a medical cannabis product also containing cannabidiol and Δ(9)-tetrahydrocannabinol: a pilot study
por: Peters, Erica N., et al.
Publicado: (2021)

S224. DELTA-9-TETRAHYDROCANNABINOL CHALLENGE IN CANNABIS USERS AND NON-USERS DIFFERENTIALLY AFFECTS BRAIN FUNCTION AND BEHAVIOR: AN FMRI STUDY OF DEVELOPMENT OF TOLERANCE
por: Colizzi, Marco, et al.
Publicado: (2018)

Cannabis sativa (Hemp) Seeds, Δ(9)-Tetrahydrocannabinol, and Potential Overdose
por: Yang, Yi, et al.
Publicado: (2017)

Cannabis, Cannabidiol Oils and Tetrahydrocannabinol—What Do Veterinarians Need to Know?
por: De Briyne, Nancy, et al.
Publicado: (2021)

Using Functional Near-Infrared Spectroscopy to Measure Effects of Delta 9-Tetrahydrocannabinol on Prefrontal Activity and Working Memory in Cannabis Users
por: Keles, Hasan O., et al.
Publicado: (2017)

Identification of candidate genes affecting Δ(9)-tetrahydrocannabinol biosynthesis in Cannabis sativa
por: Marks, M. David, et al.
Publicado: (2009)

Cannabis Use and Neuroadaptation: A Call for Δ(9)-Tetrahydrocannabinol Challenge Studies
por: Ramaekers, Johannes G., et al.
Publicado: (2022)

Indeterminacy of cannabis impairment and ∆(9)-tetrahydrocannabinol (∆(9)-THC) levels in blood and breath
por: Wurz, Gregory T., et al.
Publicado: (2022)

Application of Physiologically Based Pharmacokinetic Modeling to Predict Maternal Pharmacokinetics and Fetal Exposure to Oxcarbazepine
por: He, Lixia, et al.
Publicado: (2022)

Oral Administration of Cannabis and Δ-9-tetrahydrocannabinol (THC) Preparations: A Systematic Review
por: Poyatos, Lourdes, et al.
Publicado: (2020)

Acute effects of delta-9-tetrahydrocannabinol, cannabidiol and their combination on facial emotion recognition: A randomised, double-blind, placebo-controlled study in cannabis users
por: Hindocha, Chandni, et al.
Publicado: (2015)

Does Cannabis Composition Matter? Differential Effects of Delta-9-tetrahydrocannabinol and Cannabidiol on Human Cognition
por: Colizzi, Marco, et al.
Publicado: (2017)

Δ 9-Tetrahydrocannabinol Toxicity and Validation of Cannabidiol on Brain Dopamine Levels: An Assessment on Cannabis Duplicity
por: Chetia, Swapnali, et al.
Publicado: (2020)

Maternal Blood, Plasma, and Breast Milk Lead: Lactational Transfer and Contribution to Infant Exposure
por: Ettinger, Adrienne S., et al.
Publicado: (2013)

A Randomized, Triple-Blind, Comparator-Controlled Parallel Study Investigating the Pharmacokinetics of Cannabidiol and Tetrahydrocannabinol in a Novel Delivery System, Solutech, in Association with Cannabis Use History
por: Berl, Volker, et al.
Publicado: (2022)

Cannabis containing equivalent concentrations of delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD) induces less state anxiety than THC-dominant cannabis
por: Hutten, Nadia R. P. W., et al.
Publicado: (2022)

Cannabidiol (CBD) content in vaporized cannabis does not prevent tetrahydrocannabinol (THC)-induced impairment of driving and cognition
por: Arkell, Thomas R., et al.
Publicado: (2019)

Beyond Δ9-tetrahydrocannabinol and cannabidiol: chemical differentiation of cannabis varieties applying targeted and untargeted analysis
por: Monti, Manuela Carla, et al.
Publicado: (2022)

Intrathecal Actions of the Cannabis Constituents Δ(9)-Tetrahydrocannabinol and Cannabidiol in a Mouse Neuropathic Pain Model
por: Casey, Sherelle L., et al.
Publicado: (2022)

Acute human exposure assessment to tetrahydrocannabinol (Δ(9)‐THC)
por: Arcella, Davide, et al.
Publicado: (2020)

Prenatal alcohol and tetrahydrocannabinol exposure: Effects on spatial and working memory
por: Lei, Annie, et al.
Publicado: (2023)

Pharmacokinetics of Cannabidiol, Cannabidiolic Acid, Δ9-Tetrahydrocannabinol, Tetrahydrocannabinolic Acid and Related Metabolites in Canine Serum After Dosing With Three Oral Forms of Hemp Extract
por: Wakshlag, Joseph J., et al.
Publicado: (2020)

Assessment of Orally Administered Δ9-Tetrahydrocannabinol When Coadministered With Cannabidiol on Δ9-Tetrahydrocannabinol Pharmacokinetics and Pharmacodynamics in Healthy Adults: A Randomized Clinical Trial
por: Zamarripa, C. Austin, et al.
Publicado: (2023)

Evaluating the effect of Tetrahydrocannabinol (∆9-THC) extracted from Cannabis sativa plant on spatial memory consolidation in rats
por: Ebrhimpour, Saeedeh, et al.
Publicado: (2010)

Identification of Terpenoid Chemotypes Among High (−)-trans-Δ(9)- Tetrahydrocannabinol-Producing Cannabis sativa L. Cultivars
por: Fischedick, Justin T.
Publicado: (2017)

SNP in Potentially Defunct Tetrahydrocannabinolic Acid Synthase Is a Marker for Cannabigerolic Acid Dominance in Cannabis sativa L.
por: Garfinkel, Andrea R., et al.
Publicado: (2021)

Association of Tetrahydrocannabinol Content and Price in Herbal Cannabis Products Offered by Dispensaries in California: A Purview of Consumers/Patients
por: Dobbins, MaryBeth, et al.
Publicado: (2022)

Integration of Cannabis Extract Tetrahydrocannabinol:Cannabidiol in an Interdisciplinary Therapy Setting: A Case of Chronic Multilocular Pain Disorder
por: Romeyke, Tobias, et al.
Publicado: (2022)

Statistics on Cannabis Users Skew Perceptions of Cannabis Use
por: Burns, Rachel M., et al.
Publicado: (2013)

Physiologically Based Pharmacokinetic Modeling in Pregnant Women Suggests Minor Decrease in Maternal Exposure to Olanzapine
por: Zheng, Liang, et al.
Publicado: (2022)

Chronic exposure to ∆ (9)-tetrahydrocannabinol in adolescence decreases social play behaviours
por: Keeley, Robin, et al.
Publicado: (2021)

Safety, pharmacodynamics, and pharmacokinetics of multiple oral doses of delta-9-tetrahydrocannabinol in older persons with dementia
por: Ahmed, Amir I. A., et al.
Publicado: (2015)

Efficacy of Cannabidiol for Δ-9-Tetrahydrocannabinol-Induced Psychotic Symptoms, Schizophrenia, and Cannabis Use Disorders: A Narrative Review
por: Bartoli, Francesco, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_jdu0dbqqu3pbqnb4qvf9kvmo9a