Topoisomerase Inhibitors Increase Episomal DNA Expression by Inducing the Integration of Episomal DNA in Hepatic Cells

Gene therapy is a promising strategy to treat and cure most inherited metabolic liver disorders. Viral vectors such as those based on adeno-associated viruses (AAVs) and lentiviruses (LVs) are used as vehicles to deliver functional genes to affected hepatocytes. Adverse events associated with the us...

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Detalles Bibliográficos
Autores principales: Gómez-Moreno, Andoni, San Sebastian, Enara, Moya, Jennifer, Gomollón-Zueco, Pilar, Isola, Sergio, Vales, África, González-Aseguinolaza, Gloria, Unzu, Carmen, Garaigorta, Urtzi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10610421/
https://www.ncbi.nlm.nih.gov/pubmed/37896219
http://dx.doi.org/10.3390/pharmaceutics15102459

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10610421/
https://www.ncbi.nlm.nih.gov/pubmed/37896219
http://dx.doi.org/10.3390/pharmaceutics15102459

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