Synthesis and Biological Evaluation of Some New 3-Aryl-2-thioxo-2,3-dihydroquinazolin-4(1H)-ones and 3-Aryl-2-(benzylthio)quinazolin-4(3H)-ones as Antioxidants; COX-2, LDHA, α-Glucosidase and α-Amylase Inhibitors; and Anti-Colon Carcinoma and Apoptosis-Inducing Agents

Oxidative stress, COX-2, LDHA and hyperglycemia are interlinked contributing pathways in the etiology, progression and metastasis of colon cancer. Additionally, dysregulated apoptosis in cells with genetic alternations leads to their progression in malignant transformation. Therefore, quinazolinones...

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Detalles Bibliográficos
Autores principales: El-Sayed, Nahed Nasser Eid, Al-Otaibi, Taghreed M., Barakat, Assem, Almarhoon, Zainab M., Hassan, Mohd. Zaheen, Al-Zaben, Maha I., Krayem, Najeh, Masand, Vijay H., Ben Bacha, Abir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10610505/
https://www.ncbi.nlm.nih.gov/pubmed/37895863
http://dx.doi.org/10.3390/ph16101392

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10610505/
https://www.ncbi.nlm.nih.gov/pubmed/37895863
http://dx.doi.org/10.3390/ph16101392

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