Design of β-Keto Esters with Antibacterial Activity: Synthesis, In Vitro Evaluation, and Theoretical Assessment of Their Reactivity and Quorum-Sensing Inhibition Capacity

This work proposes the design of β-keto esters as antibacterial compounds. The design was based on the structure of the autoinducer of bacterial quorum sensing, N-(3-oxo-hexanoyl)-l-homoserine lactone (3-oxo-C6-HSL). Eight β-keto ester analogues were synthesised with good yields and were spectroscop...

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Detalles Bibliográficos
Autores principales: Martínez-Cifuentes, Maximiliano, Soto-Tapia, Emmanuel, Linares-Pipón, Camila, Bradshaw, Ben, Valenzuela-Hormazabal, Paulina, Ramírez, David, Muñoz-Torres, Patricio, Parra, Claudio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10610512/
https://www.ncbi.nlm.nih.gov/pubmed/37895810
http://dx.doi.org/10.3390/ph16101339

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10610512/
https://www.ncbi.nlm.nih.gov/pubmed/37895810
http://dx.doi.org/10.3390/ph16101339

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