Usp22 Deficiency Leads to Downregulation of PD-L1 and Pathological Activation of CD8(+) T Cells and Causes Immunopathology in Response to Acute LCMV Infection

Ubiquitin-specific peptidase 22 (Usp22) cleaves ubiquitin moieties from numerous proteins, including histone H2B and transcription factors. Recently, it was reported that Usp22 acts as a negative regulator of interferon-dependent responses. In the current study, we investigated the role of Usp22 def...

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Detalles Bibliográficos
Autores principales: Friebus-Kardash, Justa, Christ, Theresa Charlotte, Dietlein, Nikolaus, Elwy, Abdelrahman, Abdelrahman, Hossam, Holnsteiner, Lisa, Hu, Zhongwen, Rodewald, Hans-Reimer, Lang, Karl Sebastian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10610587/
https://www.ncbi.nlm.nih.gov/pubmed/37896966
http://dx.doi.org/10.3390/vaccines11101563

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10610587/
https://www.ncbi.nlm.nih.gov/pubmed/37896966
http://dx.doi.org/10.3390/vaccines11101563

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