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Usp22 Deficiency Leads to Downregulation of PD-L1 and Pathological Activation of CD8(+) T Cells and Causes Immunopathology in Response to Acute LCMV Infection
Ubiquitin-specific peptidase 22 (Usp22) cleaves ubiquitin moieties from numerous proteins, including histone H2B and transcription factors. Recently, it was reported that Usp22 acts as a negative regulator of interferon-dependent responses. In the current study, we investigated the role of Usp22 def...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10610587/ https://www.ncbi.nlm.nih.gov/pubmed/37896966 http://dx.doi.org/10.3390/vaccines11101563 |