Molecular Basis for Mambalgin-2 Interaction with Heterotrimeric α-ENaC/ASIC1a/γ-ENaC Channels in Cancer Cells

Cancer progression is characterized by microenvironmental acidification. Tumor cells adapt to low environmental pH by activating acid-sensing trimeric ion channels of the DEG/ENaC family. The α-ENaC/ASIC1a/γ-ENaC heterotrimeric channel is a tumor-specific acid-sensing channel, and its targeting can...

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Detalles Bibliográficos
Autores principales: Lyukmanova, Ekaterina N., Zaigraev, Maxim M., Kulbatskii, Dmitrii S., Isaev, Aizek B., Kukushkin, Ilya D., Bychkov, Maxim L., Shulepko, Mikhail A., Chugunov, Anton O., Kirpichnikov, Mikhail P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10610865/
https://www.ncbi.nlm.nih.gov/pubmed/37888643
http://dx.doi.org/10.3390/toxins15100612

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10610865/
https://www.ncbi.nlm.nih.gov/pubmed/37888643
http://dx.doi.org/10.3390/toxins15100612

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