Cargando…

Molecular Basis for Mambalgin-2 Interaction with Heterotrimeric α-ENaC/ASIC1a/γ-ENaC Channels in Cancer Cells

Cancer progression is characterized by microenvironmental acidification. Tumor cells adapt to low environmental pH by activating acid-sensing trimeric ion channels of the DEG/ENaC family. The α-ENaC/ASIC1a/γ-ENaC heterotrimeric channel is a tumor-specific acid-sensing channel, and its targeting can...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lyukmanova, Ekaterina N., Zaigraev, Maxim M., Kulbatskii, Dmitrii S., Isaev, Aizek B., Kukushkin, Ilya D., Bychkov, Maxim L., Shulepko, Mikhail A., Chugunov, Anton O., Kirpichnikov, Mikhail P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10610865/ https://www.ncbi.nlm.nih.gov/pubmed/37888643 http://dx.doi.org/10.3390/toxins15100612

Ejemplares similares

Mambalgin-2 Inhibits Lung Adenocarcinoma Growth and Migration by Selective Interaction With ASIC1/α-ENaC/γ-ENaC Heterotrimer
por: Sudarikova, Anastasia V., et al.
Publicado: (2022)

The N terminus of α-ENaC mediates ENaC cleavage and activation by furin
por: Kota, Pradeep, et al.
Publicado: (2018)

ENaC activation by proteases
por: Anand, Deepika, et al.
Publicado: (2022)

ENaC in Cholinergic Brush Cells
por: Kandel, Chrissy, et al.
Publicado: (2018)

Expression of ENaC subunits in epithelia
por: Frindt, Gustavo, et al.
Publicado: (2022)

Endogenous Protease Activation of ENaC: Effect of Serine Protease Inhibition on ENaC Single Channel Properties
por: Adebamiro, Adedotun, et al.
Publicado: (2005)

Regulation of ENaC trafficking in rat kidney
por: Frindt, Gustavo, et al.
Publicado: (2016)

ENaC/DEG in Tumor Development and Progression
por: Liu, Cui, et al.
Publicado: (2016)

Pendrin abundance, subcellular distribution, and function are unaffected by either αENaC gene ablation or by increasing ENaC channel activity
por: Loffing, Johannes, et al.
Publicado: (2023)

Postprandial Effects on ENaC-Mediated Sodium Absorption
por: Blass, Gregory, et al.
Publicado: (2019)

Aldosterone Modulates the Association between NCC and ENaC
por: Wynne, Brandi M., et al.
Publicado: (2017)

ENaC in Salt-Sensitive Hypertension: Kidney and Beyond
por: Pitzer, Ashley L., et al.
Publicado: (2020)

Shear force sensing of epithelial Na(+) channel (ENaC) relies on N-glycosylated asparagines in the palm and knuckle domains of αENaC
por: Knoepp, Fenja, et al.
Publicado: (2020)

CRISPR/Cas9 Mediated Knock Down of δ-ENaC Blunted the TNF-Induced Activation of ENaC in A549 Cells
por: Shabbir, Waheed, et al.
Publicado: (2021)

Function and phylogeny support the independent evolution of an ASIC-like Deg/ENaC channel in the Placozoa
por: Elkhatib, Wassim, et al.
Publicado: (2023)

Mechanosensitivity of the Epithelial Sodium Channel (ENaC): Controversy or Pseudocontroversy?
por: Rossier, Bernard C.
Publicado: (1998)

ENaC Proteolytic Regulation by Channel-activating Protease 2
por: García-Caballero, Agustín, et al.
Publicado: (2008)

There and back again: insulin, ENaC, and the cortical collecting duct
por: Pao, Alan C.
Publicado: (2016)

Does ENaC Work as Sodium Taste Receptor in Humans?
por: Bigiani, Albertino
Publicado: (2020)

Accessibility of ENaC extracellular domain central core residues
por: Zhang, Lei, et al.
Publicado: (2022)

Hypercapnia Impairs ENaC Cell Surface Stability by Promoting Phosphorylation, Polyubiquitination and Endocytosis of β-ENaC in a Human Alveolar Epithelial Cell Line
por: Gwoździńska, Paulina, et al.
Publicado: (2017)

ENaC–Membrane Interactions: Regulation of Channel Activity by Membrane Order
por: Awayda, Mouhamed S., et al.
Publicado: (2004)

Effect of ENaC Modulators on Rat Neural Responses to NaCl
por: Mummalaneni, Shobha, et al.
Publicado: (2014)

Dysregulation of ENaC in Animal Models of Nephrotic Syndrome and Liver Cirrhosis
por: Kim, Soo Wan
Publicado: (2006)

The endothelial αENaC contributes to vascular endothelial function in vivo
por: Tarjus, Antoine, et al.
Publicado: (2017)

Increased ENaC activity during kidney preservation in Wisconsin solution
por: Khedr, Sherif, et al.
Publicado: (2019)

ENaC regulation by phospholipids and DGK explained through mathematical modeling
por: Olivença, Daniel V., et al.
Publicado: (2020)

Is the ENaC Dysregulation in CF an Effect of Protein-Lipid Interaction in the Membranes?
por: Strandvik, Birgitta
Publicado: (2021)

ENaC expression correlates with the acute furosemide‐induced K(+) excretion
por: Ayasse, Niklas, et al.
Publicado: (2021)

Proteolytic ENaC activation in health and disease—a complicated puzzle
por: Althaus, Mike, et al.
Publicado: (2021)

Optogenetic Control of PIP2 Interactions Shaping ENaC Activity
por: Abd El-Aziz, Tarek Mohamed, et al.
Publicado: (2022)

DEG/ENaC/ASIC channels vary in their sensitivity to anti-hypertensive and non-steroidal anti-inflammatory drugs
por: Fechner, Sylvia, et al.
Publicado: (2021)

Mambalgin-2 Induces Cell Cycle Arrest and Apoptosis in Glioma Cells via Interaction with ASIC1a
por: Bychkov, Maxim, et al.
Publicado: (2020)

Mambalgin-2 Inhibits Growth, Migration, and Invasion of Metastatic Melanoma Cells by Targeting the Channels Containing an ASIC1a Subunit Whose Up-Regulation Correlates with Poor Survival Prognosis
por: Bychkov, Maxim L., et al.
Publicado: (2021)

Hormonal Regulation of the Epithelial Sodium Channel ENaC: N or P(o)?
por: Rossier, Bernard C.
Publicado: (2002)

A Segment of γ ENaC Mediates Elastase Activation of Na(+) Transport
por: Adebamiro, Adedotun, et al.
Publicado: (2007)

Regulation of ENaC-Mediated Sodium Reabsorption by Peroxisome Proliferator-Activated Receptors
por: Pavlov, Tengis S., et al.
Publicado: (2010)

Aldosterone and vasopressin affect α- and γ-ENaC mRNA translation
por: Perlewitz, Andrea, et al.
Publicado: (2010)

Proteolytic activation of the epithelial sodium channel (ENaC) by the cysteine protease cathepsin-S
por: Haerteis, Silke, et al.
Publicado: (2012)

Modulation of the Epithelial Sodium Channel (ENaC) by Bacterial Metalloproteases and Protease Inhibitors
por: Butterworth, Michael B., et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_050ud46cud3l1b8mf8a31imlfq