BRCA2-HSF2BP oligomeric ring disassembly by BRME1 promotes homologous recombination

In meiotic homologous recombination (HR), BRCA2 facilitates loading of the recombinases RAD51 and DMC1 at the sites of double-strand breaks (DSBs). The HSF2BP-BRME1 complex interacts with BRCA2. Its absence causes a severe reduction in recombinase loading at meiotic DSB. We previously showed that, i...

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Detalles Bibliográficos
Autores principales: Ghouil, Rania, Miron, Simona, Sato, Koichi, Ristic, Dejan, van Rossum-Fikkert, Sari E., Legrand, Pierre, Ouldali, Malika, Winter, Jean-Marie, Ropars, Virginie, David, Gabriel, Arteni, Ana-Andreea, Wyman, Claire, Knipscheer, Puck, Kanaar, Roland, Zelensky, Alex N., Zinn-Justin, Sophie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10610910/
https://www.ncbi.nlm.nih.gov/pubmed/37889963
http://dx.doi.org/10.1126/sciadv.adi7352

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10610910/
https://www.ncbi.nlm.nih.gov/pubmed/37889963
http://dx.doi.org/10.1126/sciadv.adi7352

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