Artificial Intelligence/Machine Learning-Driven Small Molecule Repurposing via Off-Target Prediction and Transcriptomics

The process of discovering small molecule drugs involves screening numerous compounds and optimizing the most promising ones, both in vitro and in vivo. However, approximately 90% of these optimized candidates fail during trials due to unexpected toxicity or insufficient efficacy. Current concepts w...

Descripción completa

Detalles Bibliográficos
Autores principales: Rao, Mohan, McDuffie, Eric, Sachs, Clifford
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10611213/
https://www.ncbi.nlm.nih.gov/pubmed/37888725
http://dx.doi.org/10.3390/toxics11100875

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10611213/
https://www.ncbi.nlm.nih.gov/pubmed/37888725
http://dx.doi.org/10.3390/toxics11100875

Ejemplares similares