Development of an In Vitro Assessment Method for Chemotherapy-Induced Peripheral Neuropathy (CIPN) by Integrating a Microphysiological System (MPS) with Morphological Deep Learning of Soma and Axonal Images

Several anticancer drugs used in cancer therapy induce chemotherapy-induced peripheral neuropathy (CIPN), leading to dose reduction or therapy cessation. Consequently, there is a demand for an in vitro assessment method to predict CIPN and mechanisms of action (MoA) in drug candidate compounds. In t...

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Detalles Bibliográficos
Autores principales: Matsuda, Kazuki, Han, Xiaobo, Matsuda, Naoki, Yamanaka, Makoto, Suzuki, Ikuro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10611258/
https://www.ncbi.nlm.nih.gov/pubmed/37888698
http://dx.doi.org/10.3390/toxics11100848

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10611258/
https://www.ncbi.nlm.nih.gov/pubmed/37888698
http://dx.doi.org/10.3390/toxics11100848

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