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Development of an In Vitro Assessment Method for Chemotherapy-Induced Peripheral Neuropathy (CIPN) by Integrating a Microphysiological System (MPS) with Morphological Deep Learning of Soma and Axonal Images

Several anticancer drugs used in cancer therapy induce chemotherapy-induced peripheral neuropathy (CIPN), leading to dose reduction or therapy cessation. Consequently, there is a demand for an in vitro assessment method to predict CIPN and mechanisms of action (MoA) in drug candidate compounds. In t...

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Detalles Bibliográficos
Autores principales:	Matsuda, Kazuki, Han, Xiaobo, Matsuda, Naoki, Yamanaka, Makoto, Suzuki, Ikuro
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10611258/ https://www.ncbi.nlm.nih.gov/pubmed/37888698 http://dx.doi.org/10.3390/toxics11100848

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