Quantitative analysis of MGMT promoter methylation in glioblastoma suggests nonlinear prognostic effect

BACKGROUND: Epigenetic inhibition of the O6-methylguanine-DNA-methyltransferase (MGMT) gene has emerged as a clinically relevant prognostic marker in glioblastoma (GBM). Methylation of the MGMT promoter has been shown to increase chemotherapy efficacy. While traditionally reported as a binary marker...

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Detalles Bibliográficos
Autores principales: Gibson, David, Ravi, Akshay, Rodriguez, Eduardo, Chang, Susan, Oberheim Bush, Nancy, Taylor, Jennie, Clarke, Jennifer, Solomon, David, Scheffler, Aaron, Witte, John, Lambing, Hannah, Okada, Hideho, Berger, Mitchel, Chehab, Farid, Butowski, Nicholas A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Basic and Translational Investigations
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10611422/
https://www.ncbi.nlm.nih.gov/pubmed/37899778
http://dx.doi.org/10.1093/noajnl/vdad115

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10611422/
https://www.ncbi.nlm.nih.gov/pubmed/37899778
http://dx.doi.org/10.1093/noajnl/vdad115

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