Cargando…

Quantitative analysis of MGMT promoter methylation in glioblastoma suggests nonlinear prognostic effect

BACKGROUND: Epigenetic inhibition of the O6-methylguanine-DNA-methyltransferase (MGMT) gene has emerged as a clinically relevant prognostic marker in glioblastoma (GBM). Methylation of the MGMT promoter has been shown to increase chemotherapy efficacy. While traditionally reported as a binary marker...

Descripción completa

Detalles Bibliográficos
Autores principales:	Gibson, David, Ravi, Akshay, Rodriguez, Eduardo, Chang, Susan, Oberheim Bush, Nancy, Taylor, Jennie, Clarke, Jennifer, Solomon, David, Scheffler, Aaron, Witte, John, Lambing, Hannah, Okada, Hideho, Berger, Mitchel, Chehab, Farid, Butowski, Nicholas A
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2023
Materias:	Basic and Translational Investigations
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10611422/ https://www.ncbi.nlm.nih.gov/pubmed/37899778 http://dx.doi.org/10.1093/noajnl/vdad115

Ejemplares similares

NGMA-6. Quantitative MGMT Promoter Methylation Index Indicates Non-Linear, Prognostic Effect in Glioblastoma
por: Gibson, David, et al.
Publicado: (2021)

TGF-β1 modulates temozolomide resistance in glioblastoma via altered microRNA processing and elevated MGMT
por: Nie, Er, et al.
Publicado: (2020)

Prognostic impact of PDGFRA gain/amplification and MGMT promoter methylation status in patients with IDH wild-type glioblastoma
por: Higa, Nayuta, et al.
Publicado: (2022)

PARP-mediated PARylation of MGMT is critical to promote repair of temozolomide-induced O(6)-methylguanine DNA damage in glioblastoma
por: Wu, Shaofang, et al.
Publicado: (2021)

Improved risk stratification in younger IDH wild-type glioblastoma patients by combining a 4-miRNA signature with MGMT promoter methylation status
por: Unger, Kristian, et al.
Publicado: (2020)

Absence of the MGMT protein as well as methylation of the MGMT promoter predict the sensitivity for temozolomide
por: van Nifterik, K A, et al.
Publicado: (2010)

Parents’ experiences of postmortem tumor donation for high-grade gliomas: benefits and suggested improvements
por: Robertson, Eden G, et al.
Publicado: (2021)

An independently validated nomogram for isocitrate dehydrogenase-wild-type glioblastoma patient survival
por: Gittleman, Haley, et al.
Publicado: (2019)

GBMdeconvoluteR accurately infers proportions of neoplastic and immune cell populations from bulk glioblastoma transcriptomics data
por: Ajaib, Shoaib, et al.
Publicado: (2023)

MGMT gene promoter methylation correlates with tolerance of temozolomide treatment in melanoma but not with clinical outcome
por: Hassel, J C, et al.
Publicado: (2010)

The state of neuro-oncology during the COVID-19 pandemic: a worldwide assessment
por: Mrugala, Maciej M, et al.
Publicado: (2021)

Diffuse non-midline glioma with H3F3A K27M mutation: a prognostic and treatment dilemma
por: López, Giselle, et al.
Publicado: (2017)

Targeting the TREM1-positive myeloid microenvironment in glioblastoma
por: Filippova, Natalia, et al.
Publicado: (2022)

Temozolomide- and fotemustine-induced apoptosis in human malignant melanoma cells: response related to MGMT, MMR, DSBs, and p53
por: Naumann, S C, et al.
Publicado: (2009)

Radiogenomic modeling predicts survival-associated prognostic groups in glioblastoma
por: Nuechterlein, Nicholas, et al.
Publicado: (2021)

Screening of predicted synergistic multi-target therapies in glioblastoma identifies new treatment strategies
por: Houweling, Megan, et al.
Publicado: (2023)

Prospective prediction of clinical drug response in high-grade gliomas using an ex vivo 3D cell culture assay
por: Shuford, Stephen, et al.
Publicado: (2021)

MGMT promoter hypermethylation and K-RAS, PTEN and TP53 mutations in tamoxifen-exposed and non-exposed endometrial cancer cases
por: Nagy, E, et al.
Publicado: (2014)

MicroRNA-93 acts as an “anti-inflammatory tumor suppressor” in glioblastoma
por: Hübner, Max, et al.
Publicado: (2020)

Hyaluronan inhibits expression of ADAMTS4 (aggrecanase-1) in human osteoarthritic chondrocytes
por: Yatabe, T, et al.
Publicado: (2009)

Single-cell transcriptomic analyses provide insights into the cellular origins and drivers of brain metastasis from lung adenocarcinoma
por: Wang, Zihao, et al.
Publicado: (2023)

Metabolism-based isolation of invasive glioblastoma cells with specific gene signatures and tumorigenic potential
por: Smith, Stuart James, et al.
Publicado: (2020)

Glioblastoma extracellular vesicles influence glial cell hyaluronic acid deposition to promote invasiveness
por: Koessinger, Dominik, et al.
Publicado: (2023)

Longitudinal drug synergy assessment using convolutional neural network image-decoding of glioblastoma single-spheroid cultures
por: Giczewska, Anna, et al.
Publicado: (2023)

Multireceptor targeting of glioblastoma
por: Sharma, Puja, et al.
Publicado: (2020)

An investigation of the conformity, feasibility, and expected clinical benefits of multiparametric MRI-guided dose painting radiotherapy in glioblastoma
por: Brighi, Caterina, et al.
Publicado: (2022)

A ”Clickable” Probe for Active MGMT in Glioblastoma Demonstrates Two Discrete Populations of MGMT
por: Raghavan, Sudhir, et al.
Publicado: (2020)

Near haploidization is a genomic hallmark which defines a molecular subgroup of giant cell glioblastoma
por: Baker, Tiffany G, et al.
Publicado: (2020)

Surgical resection of glioblastomas induces pleiotrophin-mediated self-renewal of glioblastoma stem cells in recurrent tumors
por: Knudsen, Arnon Møldrup, et al.
Publicado: (2021)

Temporospatial genomic profiling in glioblastoma identifies commonly altered core pathways underlying tumor progression
por: Blomquist, Mylan R, et al.
Publicado: (2020)

A single institution retrospective analysis on survival based on treatment paradigms for patients with anaplastic oligodendroglioma
por: Bush, Nancy Ann Oberheim, et al.
Publicado: (2021)

Genetic variations in EGF and EGFR and glioblastoma outcome
por: Sjöström, Sara, et al.
Publicado: (2010)

CRN2 enhances the invasiveness of glioblastoma cells
por: Ziemann, Anja, et al.
Publicado: (2013)

GammaTile® brachytherapy in the treatment of recurrent glioblastomas
por: Gessler, Dominic J, et al.
Publicado: (2021)

Expression of pluripotency-related genes in human glioblastoma
por: Rios, Álvaro Fabrício Lopes, et al.
Publicado: (2021)

On optimal temozolomide scheduling for slowly growing glioblastomas
por: Segura-Collar, Berta, et al.
Publicado: (2022)

Comprehensive molecular characterization of multifocal glioblastoma proves its monoclonal origin and reveals novel insights into clonal evolution and heterogeneity of glioblastomas
por: Abou-El-Ardat, Khalil, et al.
Publicado: (2017)

Randomized trial of neoadjuvant vaccination with tumor-cell lysate induces T cell response in low-grade gliomas
por: Ogino, Hirokazu, et al.
Publicado: (2022)

NCoR controls glioblastoma tumor cell characteristics
por: Heldring, Nina, et al.
Publicado: (2014)

Sprouty2 enhances the tumorigenic potential of glioblastoma cells
por: Park, Jong-Whi, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_gategar8mf56ep7jdglmgvfdrh