Early activation of cellular stress and death pathways caused by cytoplasmic TDP-43 in the rNLS8 mouse model of ALS and FTD

TAR DNA binding protein 43 (TDP-43) pathology is a key feature of over 95% of amyotrophic lateral sclerosis (ALS) and nearly half of frontotemporal dementia (FTD) cases. The pathogenic mechanisms of TDP-43 dysfunction are poorly understood, however, activation of cell stress pathways may contribute...

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Detalles Bibliográficos
Autores principales: Luan, Wei, Wright, Amanda L., Brown-Wright, Heledd, Le, Sheng, San Gil, Rebecca, Madrid San Martin, Lidia, Ling, Karen, Jafar-Nejad, Paymaan, Rigo, Frank, Walker, Adam K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10611572/
https://www.ncbi.nlm.nih.gov/pubmed/37012334
http://dx.doi.org/10.1038/s41380-023-02036-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10611572/
https://www.ncbi.nlm.nih.gov/pubmed/37012334
http://dx.doi.org/10.1038/s41380-023-02036-9

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