Folding correctors can restore CFTR posttranslational folding landscape by allosteric domain–domain coupling

The folding/misfolding and pharmacological rescue of multidomain ATP-binding cassette (ABC) C-subfamily transporters, essential for organismal health, remain incompletely understood. The ABCC transporters core consists of two nucleotide binding domains (NBD1,2) and transmembrane domains (TMD1,2). Us...

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Detalles Bibliográficos
Autores principales: Soya, Naoto, Xu, Haijin, Roldan, Ariel, Yang, Zhengrong, Ye, Haoxin, Jiang, Fan, Premchandar, Aiswarya, Veit, Guido, Cole, Susan P. C., Kappes, John, Hegedüs, Tamás, Lukacs, Gergely L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10611759/
https://www.ncbi.nlm.nih.gov/pubmed/37891162
http://dx.doi.org/10.1038/s41467-023-42586-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10611759/
https://www.ncbi.nlm.nih.gov/pubmed/37891162
http://dx.doi.org/10.1038/s41467-023-42586-8

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