Cargando…

Chronic administration of XBD173 ameliorates cognitive deficits and neuropathology via 18 kDa translocator protein (TSPO) in a mouse model of Alzheimer’s disease

Alzheimer’s disease (AD) is characterized by the accumulation of β-amyloid peptide (Aβ). It affects cognition and leads to memory impairment. The mitochondrial translocator protein (TSPO) plays an essential role in maintaining mitochondrial homeostasis and has been implicated in several neuronal dis...

Descripción completa

Detalles Bibliográficos
Autores principales:	Pradhan, Arpit Kumar, Neumüller, Tatjana, Klug, Claudia, Fuchs, Severin, Schlegel, Martin, Ballmann, Markus, Tartler, Katharina Johanna, Pianos, Antoine, Garcia, Maria Sanchez, Liere, Philippe, Schumacher, Michael, Kreuzer, Matthias, Rupprecht, Rainer, Rammes, Gerhard
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10611770/ https://www.ncbi.nlm.nih.gov/pubmed/37891168 http://dx.doi.org/10.1038/s41398-023-02630-z

Ejemplares similares

The agonistic TSPO ligand XBD173 attenuates the glial response thereby protecting inner retinal neurons in a murine model of retinal ischemia
por: Mages, Kristin, et al.
Publicado: (2019)

Human pharmacokinetics of XBD173 and etifoxine distinguish their potential for pharmacodynamic effects mediated by translocator protein
por: Owen, David R., et al.
Publicado: (2022)

Translocator protein (18 kDa) (TSPO) is expressed in reactive retinal microglia and modulates microglial inflammation and phagocytosis
por: Karlstetter, Marcus, et al.
Publicado: (2014)

18 kDa Translocator Protein TSPO Is a Mediator of Astrocyte Reactivity
por: Tournier, Benjamin B., et al.
Publicado: (2023)

The Comprehensive Steroidome in Complete TSPO/PBR Knockout Mice under Basal Conditions
por: Liere, Philippe, et al.
Publicado: (2023)

Impact of Translocator Protein 18 kDa (TSPO) Deficiency on Mitochondrial Function and the Inflammatory State of Human C20 Microglia Cells
por: Bader, Stefanie, et al.
Publicado: (2023)

Translocator Protein 18 kDa (TSPO) Is Regulated in White and Brown Adipose Tissue by Obesity
por: Thompson, Misty M., et al.
Publicado: (2013)

A Novel Interaction of Translocator Protein 18 kDa (TSPO) with NADPH Oxidase in Microglia
por: Loth, Meredith K., et al.
Publicado: (2020)

Translocator Protein 18 kDa (TSPO) as a Novel Therapeutic Target for Chronic Pain
por: Liu, Jie, et al.
Publicado: (2022)

Regulation of Translocator Protein 18 kDa (TSPO) Expression in Rat and Human Male Germ Cells
por: Manku, Gurpreet, et al.
Publicado: (2016)

Translocator Protein 18 kDa (TSPO) Deficiency Inhibits Microglial Activation and Impairs Mitochondrial Function
por: Yao, Rumeng, et al.
Publicado: (2020)

Imaging adipose tissue browning using the TSPO-18kDa tracer [(18)F]FEPPA
por: Hartimath, S.V., et al.
Publicado: (2019)

In vitro and pilot in vivo imaging of 18 kDa translocator protein (TSPO) in inflammatory vascular disease
por: Schollhammer, Romain, et al.
Publicado: (2021)

Quantification of astrocytic synaptic pruning in mouse hippocampal slices in response to ex vivo Aβ treatment via colocalization analysis with C1q
por: Pradhan, Arpit Kumar, et al.
Publicado: (2022)

Bipolar Disorder is associated with the rs6971 polymorphism in the gene encoding 18 kDa Translocator Protein (TSPO)()
por: Colasanti, Alessandro, et al.
Publicado: (2013)

Characterization of the 18 kDa translocator protein (TSPO) expression in post‐mortem normal and Alzheimer's disease brains
por: Gui, Yaxing, et al.
Publicado: (2019)

Activated microglia do not increase 18 kDa translocator protein (TSPO) expression in the multiple sclerosis brain
por: Nutma, Erik, et al.
Publicado: (2021)

Neurogenic Potential of the 18-kDa Mitochondrial Translocator Protein (TSPO) in Pluripotent P19 Stem Cells
por: González-Blanco, Laura, et al.
Publicado: (2021)

Translocator protein (18kDA) (TSPO) marks mesenchymal glioblastoma cell populations characterized by elevated numbers of tumor-associated macrophages
por: Weidner, Lorraine, et al.
Publicado: (2023)

An 18-kDa Translocator Protein (TSPO) polymorphism explains differences in binding affinity of the PET radioligand PBR28
por: Owen, David R, et al.
Publicado: (2012)

The 18-kDa Translocator Protein (TSPO) Disrupts Mammary Epithelial Morphogenesis and Promotes Breast Cancer Cell Migration
por: Wu, Xiaoting, et al.
Publicado: (2013)

Translocator protein 18 kDa (TSPO): old dogma, new mice, new structure, and new questions for neuroprotection
por: Kim, Eun-Jung, et al.
Publicado: (2015)

Current paradigm of the 18-kDa translocator protein (TSPO) as a molecular target for PET imaging in neuroinflammation and neurodegenerative diseases
por: Ching, Alex Sik Chung, et al.
Publicado: (2011)

Targeting translocator protein (18 kDa) (TSPO) dampens pro-inflammatory microglia reactivity in the retina and protects from degeneration
por: Scholz, Rebecca, et al.
Publicado: (2015)

Translocator Protein-18 kDa (TSPO) Positron Emission Tomography (PET) Imaging and Its Clinical Impact in Neurodegenerative Diseases
por: Dupont, Anne-Claire, et al.
Publicado: (2017)

In vivo evaluation of a novel (18)F-labeled PET radioligand for translocator protein 18 kDa (TSPO) in monkey brain
por: Yan, Xuefeng, et al.
Publicado: (2023)

Differential effects of the translocator protein 18 kDa (TSPO) ligand etifoxine and the benzodiazepine alprazolam on startle response to predictable threat in a NPU-threat task after acute and short-term treatment
por: Brunner, Lisa-Marie, et al.
Publicado: (2022)

TSPO as a target for treatments of diseases, including neuropathological disorders
por: Veenman, L, et al.
Publicado: (2015)

Cloning and promoter analysis of palladin 90-kDa, 140-kDa, and 200-kDa isoforms involved in skeletal muscle cell maturation
por: Ouali, Boimpoundi Eunice Flavie, et al.
Publicado: (2020)

Systematic Analysis of Translocator Protein 18 kDa (TSPO) Ligands on Toll-like Receptors-mediated Pro-inflammatory Responses in Microglia and Astrocytes
por: Lee, Ji-Won, et al.
Publicado: (2016)

Lentiviral-Mediated Overexpression of the 18 kDa Translocator Protein (TSPO) in the Hippocampal Dentate Gyrus Ameliorates LPS-Induced Cognitive Impairment in Mice
por: Wang, Wei, et al.
Publicado: (2016)

[(125) I]IodoDPA-713 Binding to 18 kDa Translocator Protein (TSPO) in a Mouse Model of Intracerebral Hemorrhage: Implications for Neuroimaging
por: Bonsack, Frederick, et al.
Publicado: (2018)

Data on physicochemical properties of LPEI 25 kDa, PEI“Max” 40 kDa and PEIpro™
por: Delafosse, Laurence, et al.
Publicado: (2016)

Expression of mitochondrial TSPO and FAM173B is associated with inflammation and symptoms in patients with painful knee osteoarthritis
por: Palada, Vinko, et al.
Publicado: (2020)

In Vitro Inhibition of Angiogenesis by Antibodies Directed against the 37kDa/67kDa Laminin Receptor
por: Khusal, Raksha, et al.
Publicado: (2013)

Expression of the 60 kDa and 71 kDa heat shock proteins and presence of antibodies against the 71 kDa heat shock protein in pediatric patients with immune thrombocytopenic purpura
por: Xiao, Chengfeng, et al.
Publicado: (2004)

The 37kDa/67kDa Laminin Receptor acts as a receptor for Aβ(42) internalization
por: Da Costa Dias, Bianca, et al.
Publicado: (2014)

Knock-Down of the 37kDa/67kDa Laminin Receptor LRP/LR Impedes Telomerase Activity
por: Naidoo, Kerrilyn, et al.
Publicado: (2015)

The 18 kDa Translocator Protein (TSPO) Overexpression in Hippocampal Dentate Gyrus Elicits Anxiolytic-Like Effects in a Mouse Model of Post-traumatic Stress Disorder
por: Zhang, Xiao-Ying, et al.
Publicado: (2018)

Enhanced gene transfection efficiency by low-dose 25 kDa polyethylenimine by the assistance of 1.8 kDa polyethylenimine
por: Zhang, Hui, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_em6uvs4si061ip03d5j0m2vi0l