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Hydrophobic gating in bundle-crossing ion channels: a case study of TRPV4
Transmembrane ion channels frequently regulate ion permeation by forming bundle crossing of the pore-lining helices when deactivated. The resulting physical constriction is believed to serve as the de facto gate that imposes the major free energy barrier to ion permeation. Intriguingly, many ion cha...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group UK
2023
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10611814/ https://www.ncbi.nlm.nih.gov/pubmed/37891195 http://dx.doi.org/10.1038/s42003-023-05471-0 |