HIV-1 Resistance to Islatravir/Tenofovir Combination Therapy in Wild-Type or NRTI-Resistant Strains of Diverse HIV-1 Subtypes

Tenofovir disoproxil fumarate (TDF) and islatravir (ISL, 4′-ethynyl-2-fluoro-2′-deoxyadensine, or MK-8591) are highly potent nucleoside reverse transcriptase inhibitors. Resistance to TDF and ISL is conferred by K65R and M184V, respectively. Furthermore, K65R and M184V increase sensitivity to ISL an...

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Detalles Bibliográficos
Autores principales: Cilento, Maria E., Wen, Xin, Reeve, Aaron B., Ukah, Obiaara B., Snyder, Alexa A., Carrillo, Ciro M., Smith, Cole P., Edwards, Kristin, Wahoski, Claudia C., Kitzler, Deborah R., Kodama, Eiichi N., Mitsuya, Hiroaki, Parniak, Michael A., Tedbury, Philip R., Sarafianos, Stefan G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10612037/
https://www.ncbi.nlm.nih.gov/pubmed/37896768
http://dx.doi.org/10.3390/v15101990

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10612037/
https://www.ncbi.nlm.nih.gov/pubmed/37896768
http://dx.doi.org/10.3390/v15101990

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