Pharmacokinetic and Pharmacodynamic Analysis of the 3CL Protease Inhibitor Ensitrelvir in a SARS-CoV-2 Infection Mouse Model

The small-molecule antiviral drug ensitrelvir targets the 3C-like protease of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This study evaluated its inhibitory effect on viral replication in a delayed-treatment mouse model and investigated the relationship between pharmacokinetic (PK...

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Detalles Bibliográficos
Autores principales: Fukao, Keita, Nobori, Haruaki, Kuroda, Takayuki, Baba, Kaoru, Matsumoto, Kazumi, Tanaka, Yukari, Tachibana, Yuki, Kato, Teruhisa, Shishido, Takao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10612060/
https://www.ncbi.nlm.nih.gov/pubmed/37896829
http://dx.doi.org/10.3390/v15102052

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10612060/
https://www.ncbi.nlm.nih.gov/pubmed/37896829
http://dx.doi.org/10.3390/v15102052

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