CD28/PD1 co-expression: dual impact on CD8(+) T cells in peripheral blood and tumor tissue, and its significance in NSCLC patients' survival and ICB response

BACKGROUND: Immune checkpoint blockade (ICB) has significantly prolonged survival of non-small cell lung cancer (NSCLC) patients, although most patients develop mechanisms of resistance. Recently single-cell RNA-sequencing (scRNA-Seq) revealed a huge T-cell phenotypic and (dys)functional state varia...

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Detalles Bibliográficos
Autores principales: Palermo, Belinda, Franzese, Ornella, Frisullo, Giuseppe, D’Ambrosio, Lorenzo, Panetta, Mariangela, Campo, Giulia, D’Andrea, Daniel, Sperduti, Isabella, De Nicola, Francesca, Goeman, Frauke, Gallina, Filippo, Visca, Paolo, Facciolo, Francesco, Nisticò, Paola
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10612243/
https://www.ncbi.nlm.nih.gov/pubmed/37898752
http://dx.doi.org/10.1186/s13046-023-02846-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10612243/
https://www.ncbi.nlm.nih.gov/pubmed/37898752
http://dx.doi.org/10.1186/s13046-023-02846-3

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