Increased binding of anti-dsDNA antibodies to short oligonucleotides modified with topoisomerase I reveals a potential new enzyme function independent from DNA relaxation

OBJECTIVE: Topoisomerase I (topo I) is a highly conserved enzyme which is known to reduce torsional stress at double-stranded (ds) DNA. Torsional stress induced by supercoiling of dsDNA requires either very long dsDNA existing in genomic DNA or circulation as presented in plasmid DNA. To enable DNA...

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Detalles Bibliográficos
Autores principales: Frese-Schaper, Manuela, Voll, Reinhard E., Frese, Steffen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research Note
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10612351/
https://www.ncbi.nlm.nih.gov/pubmed/37898816
http://dx.doi.org/10.1186/s13104-023-06592-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10612351/
https://www.ncbi.nlm.nih.gov/pubmed/37898816
http://dx.doi.org/10.1186/s13104-023-06592-9

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