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DNA methylation of insulin signaling pathways is associated with HOMA2-IR in primary myoblasts from older adults

BACKGROUND: While ageing is associated with increased insulin resistance (IR), the molecular mechanisms underlying increased IR in the muscle, the primary organ for glucose clearance, have yet to be elucidated in older individuals. As epigenetic processes are suggested to contribute to the developme...

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Detalles Bibliográficos
Autores principales:	Burton, Mark A., Garratt, Emma S., Hewitt, Matthew O., Sharkh, Hanan Y., Antoun, Elie, Westbury, Leo D., Dennison, Elaine M., Harvey, Nicholas C., Cooper, Cyrus, MacIsaac, Julia L., Kobor, Michael S., Patel, Harnish P., Godfrey, Keith M., Lillycrop, Karen A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10612387/ https://www.ncbi.nlm.nih.gov/pubmed/37898813 http://dx.doi.org/10.1186/s13395-023-00326-y

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