Deubiquitinase OTUD5 promotes hepatitis B virus replication by removing K48-linked ubiquitination of HBV core/precore and upregulates HNF4ɑ expressions by inhibiting the ERK1/2/mitogen-activated protein kinase pathway

Hepatitis B virus (HBV) infection is a major public health problem worldwide, causing nearly one million deaths annually. OTUD5 is a deubiquitinase associated with cancer development and innate immunity response. However, the regulatory mechanisms of OTUD5 underlying HBV replication need to be deepl...

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Detalles Bibliográficos
Autores principales: Lou, Bin, Ma, Guanghua, Yu, Xiaopeng, Lv, Feifei, Xu, Fanjie, Sun, Chengdi, Chen, Yu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10613150/
https://www.ncbi.nlm.nih.gov/pubmed/37897511
http://dx.doi.org/10.1007/s00018-023-04995-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10613150/
https://www.ncbi.nlm.nih.gov/pubmed/37897511
http://dx.doi.org/10.1007/s00018-023-04995-2

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