α-Synuclein aggregates amplified from patient-derived Lewy bodies recapitulate Lewy body diseases in mice

Extraction of α-Synuclein (αSyn) aggregates from Lewy body disease (LBD) brains has been widely described yet templated fibrillization of LB-αSyn often fails to propagate its structural and functional properties. We recently demonstrated that aggregates amplified from LB-αSyn (ampLB) show distinct b...

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Detalles Bibliográficos
Autores principales: Uemura, Norihito, Marotta, Nicholas P., Ara, Jahan, Meymand, Emily S., Zhang, Bin, Kameda, Hiroshi, Koike, Masato, Luk, Kelvin C., Trojanowski, John Q., Lee, Virginia M.-Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10613245/
https://www.ncbi.nlm.nih.gov/pubmed/37898614
http://dx.doi.org/10.1038/s41467-023-42705-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10613245/
https://www.ncbi.nlm.nih.gov/pubmed/37898614
http://dx.doi.org/10.1038/s41467-023-42705-5

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